A complete of three % of Lively substance is excreted in urine as unchanged Lively material. Tapentadol is additionally metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 and also to hydroxy tapentadol (two %) by CYP2D6, which happen to be additional metabolised by conjugation. For that reason, Lively substance metabolism mediated b